Wednesday, July 1, 2009


Propofol Sandoz is used as a short acting general anaesthetic. It may be given to you by injection before an operation to produce general anaesthesia. This is the condition of heavy sleep needed during surgery. Propofol Sandoz can also be used to start off an anaesthetic (induction anaesthesia). This means that the anaesthetist may change over to a gas anaesthetic after you have gone to sleep. During some short medical procedures, Propofol Sandoz may also be given to you slowly in low doses to sedate you, or make you sleepy. However, your anaesthetist or surgeon may have prescribed Propofol Sandoz for another reason. Ask your doctor if you have any questions about why Propofol Sandoz has been prescribed for you. This medicine is available only with a doctor's prescription.

Propofol Sandoz is given by an injection into a vein, usually in the forearm or the back of the hand. Your anaesthetist will decide what dose and how long you will receive Propofol Sandoz. The dose of Propofol Sandoz will be adjusted to keep you at the right depth of sleep or sedation. If you are older, a child, or have some kind of heart condition, your anaesthetist may be able to use lower doses to get the right depth of sleep or sedation.

Your anaesthetist, surgeon and nursing staff are trained to look after every need that you have while you are asleep or sedated. If you are receiving Propofol Sandoz for general anaesthesia the anaesthetist may need to use several different medicines to keep you asleep, pain free, breathing in a healthy way and with good blood pressure. If you are receiving Propofol Sandoz for sedation, other drugs may also be given at the same time for pain relief. The mix and doses of drugs needs to be chosen by specially trained doctors and adjusted for each patient according to their need.

All medicines can have side effects. Sometimes they are serious most of the time they are not. You may need medical treatment if you get some of the side effects. Some of the unwanted side effects of Propofol Sandoz are the result of sleep being too light or too deep. Your anaesthetist will reduce the dose of Propofol Sandoz if your blood pressure is low, or if you need help breathing. However, your anaesthetist may increase the dose if body movement is still observed. Other medicines may also be needed if your heart rate becomes too slow or irregular. There may be an increased risk of fits or convulsions in patients with epilepsy. The anaesthetist is trained to manage these rare events in the unlikely event that they occur. Rarely, major allergic reactions called anaphylaxis have occurred following the use of Propofol Sandoz. These reactions occur during operations and may include drop of blood pressure, spasm, or tightness of the bronchi (breathing tubes) and redness of the skin. The anaesthetist is trained to manage these rare events if they occur.

More questions about Michael Jackson’s medications arose Tuesday when a nurse came forward to say that Jackson had asked her in April for a power sedative.

Cherilyn Lee, a registered nurse who operates a Los Angeles-based nutritional counseling business, told CNN that Jackson was complaining of insomnia and pleaded for her to get him some Diprivan (propofol), a drug usually used to start or maintain anesthesia during surgeries.

Lee said she told Jackson “the medication is not safe.”

Four days before Jackson’s death, Lee said, a Jackson staffer called and said the pop star was complaining that one side of his body was hot and the other side was cold .

“You need to go to hospital,” she told the staffer, with Jackson apparently in earshot.

An injection of Diprivan can induce hypnosis within 40 seconds from the start of injection, according to the U.S. Food and Drug Administration.

The drug’s product label says that propofol should only be administered by people “trained in the administration of general anesthesia.” Sedated patients should be continuously monitored, the product label says, and equipment to provide artificial ventilation, administration of oxygen and instituting CPR “must be immediately available.”

The product label warns that use of propofol for sedating adult and pediatric intensive care unit patients has been associated with organ system failures that have resulted in death.